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Pragmatic trials are studies designed to inform the practice of clinical trials in real life. They are often described as a focus on the practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from various geographical areas. This type of heterogeneity is required for practical trials to be valid and also reduces the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.

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The purpose of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are typically ordered by policymakers and practitioners to help inform their decisions. They can be used to determine the causality of an intervention and its results. However, they should not be used in lieu for explanation trials.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide the policy and practice of. They also suggested a framework known as PRECIS for 프라그마틱 무료체험 슬롯버프 pragmatic trials.2 The tool was designed to define the characteristics of a practical study which includes the recruitment, design, and delivery of the intervention, and follow-up.

There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more sensitive to the subject of pragmatic thinking. It is important to note that the majority of studies were conducted in primary-care settings.