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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described as focusing on practical aspects of designing a study that include recruitment and consent, adherence and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from different geographical regions. This type of heterogeneity that is crucial for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However too much heterogeneity could lead to issues with the design of the trial.

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Mobile compatibility

Pragmatic Play, a relatively young player in the industry of casinos on the internet, has gained recognition for its mobile-friendly slot machines. Their games are optimized for mobile devices, and run using HTML5 technology. They're also certified by trusted gaming authorities to ensure fairness and transparency. This is a great indication for players as it means that the games are examined and verified to make sure that the results of every round are random and unbiased.

Pragmatic Play offers not only mobile-friendly slot machines as well as tables games and live casinos. The company is licensed by a variety of regulatory bodies such as Malta Gaming Authority and UK Gambling Commission. The games are supported by high-end encryption and the security team is available to assist players with any issues they might face.

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The goal of pragmatic trials is to replicate real-life situations and achieve maximum validity externally. Usually, they are requested by practitioners and policymakers to help inform their decisions. They can be used to determine the causal relationship between an intervention with its outcomes. However, they shouldn't be used in lieu for the use of explanation studies.

The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm a physiological or 무료슬롯 프라그마틱 clinical hypothesis, and pragmatic trials, which inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a practical study that includes recruitment, design, implementation of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to remember, however, that the majority were conducted in primary-care settings.