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Pragmatic Play Free Trial

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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically focused on practical aspects of the research design, like the recruitment and consent process as well as adherence to the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from different geographic areas. This type of heterogeneity which is essential for pragmatic trials to be valid and reduce bias in results is also essential. However, too much heterogeneity can result in problems with the design of the trial.

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The aim of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are usually requested by practitioners and policymakers to help inform their decisions. They are also a good method to determine the cause-effect relationship between the intervention and its effects. However, they shouldn't be used in lieu for the use of explanation trials.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate a physiological or clinical hypothesis and pragmatic trials, which guide the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study which includes recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary-care settings.